Disclosed are a method and apparatus for self-training of machine reading comprehension to improve domain adaptation. The method for self-training of the machine reading comprehension may include generating a pseudo training data set comprising pseudo-questions and pseudo-answers in response to a change in a domain to which a trained machine reading comprehension model is to be applied, refining the pseudo training data set, and retraining the machine reading comprehension model and a pseudo-question generator that generates the pseudo-questions using the refined pseudo training data set.